Dietetics & Nutrition Technology (Formulation)
Scientist
Formulation & Drug Delivery
01894-233339 Ext: 485
PhD
CV.pdf
(i) Development of value added products from aromatics and herbals
 

India is gifted with 8000 medicinal and 1200-2500 aromatic plants. They have been extensively used for the preparation of drugs in various systems of medicine, herbal cosmetics and functional foods. Further, essential oils from aromatic plants have also been extensively used in flavour, fragrance, cosmetics industries and in aromatherapy. The main focus of our laboratory is to develop value added products from medicinal and aromatic plants utilizing pharmaceutical technology (formulations) to produce commercially marketable products.

 
 
(ii) Development of nutraceutical formulations for improvement of bioavailability and therapeutic efficacy
 

The consumption of dietary phytochemicals is consistently linked with protection from chronic diseases such as diabetes, cardiovascular disease, cancer and neurodegenerative diseases. However, these phytochemicals have major therapeutic limitations because of their low aqueous solubility, low permeability, short half-life and low bioavailability to humans. These limitations can be overcome by advanced pharmaceutical technologies. The current theme of our laboratory is to utilize self-emulsifying drug delivery systems (SEDDS), solid dispersions, nano-emulsions and polymeric particles based approaches to enhance the bioavailability as well as therapeutic efficacy of nutraceuticals.

Awards to Group:

Ms. Ruchika and Mr. Rakesh Kumar Dhritlahre (PhD Fellows) received prestigious IGSTC Industrial Fellowship 2022.

Mr. Nabab Khan (PhD Fellow) received prestigious IGSTC Industrial Fellowship 2023.

International Awards

CEFIPRA-ESONN fellowship for participation in “European School on Nanosciences and Nanotechnologies” on 28th August – 17th September, 2016 held at Grenoble, France.

PSE Travel Bursary for participation in “Natural Products in Health, Agro Food and Cosmetics” meeting from June 28th – July 1st, 2017 held at Lille, France.

Bioencapsulation Research Grant for participation in “25th International Conference on Bioencapsulation” on 3-6 July, 2017 held at Nantes, France.

Lapervenchelif award for participation in “The 5th AFERP International Conference "Pharmacognosy from Here and There" from July 17th to 19th 2017 held at Angers, France.

 FAPESP grant for attending "São Paulo School of Advanced Science on Reverse Engineering of Processed Foods” from September 25th – October 4th, 2017 held at at UNICAMP, Brazil.

DST-SERB International Travel Support for participation in “19th OXFORD ICSB, USA” on 8th April – 11th April, 2019 held at Oxford, Mississippi, USA.

 Achievements:

Qualified All India G.P.A.T. [Graduate Pharmacy Aptitude Test] 2010, 2012, G.A.T.E. [Graduate Aptitude Test in Engineering] 2012, 2016 Life Science (XL). (AIR: 303, GATE XL: 2016)

Selected Research Publications as Corresponding Author (Recent Five)

  1. Khan, N., Slathia G., Saneja, A.* (2023) Unveiling the complexation mechanism of phloretin with Sulfobutylether–β–cyclodextrin (Captisol®) and its impact on anticancer activity. Journal of Molecular Liquids, 391, 123348. https://doi.org/10.1016/j.molliq.2023.123348  (IF:6.0) (Corresponding Author)
  2. Ruchika, Bhardwaj, N., Saneja, A.* (2024). Orally Fast Dissolving α-Lipoic acid Electrospun Nanofibers Mitigates Lipopolysaccharide Induced Inflammation in RAW 264.7 Macrophages. International Journal of Biological Macromolecules, 130623. https://doi.org/10.1016/j.ijbiomac.2024.130623  (IF:8.2) (Corresponding Author)
  3. Khan, N., Bhardwaj, V. K., Ruchika, Purohit, R., Saneja, A.* (2023). Deciphering the interactions of genistein with β-cyclodextrin derivatives through experimental and microsecond timescale umbrella sampling simulations. Journal of Molecular Liquids, 121295. https://doi.org/10.1016/j.molliq.2023.121295 (IF:6.0) (Corresponding Author)
  4. Khan, N., Singh, A. K., Saneja, A.* (2023). Preparation, Characterization, and Antioxidant Activity of L-Ascorbic Acid/HP-β-Cyclodextrin Inclusion Complex-Incorporated Electrospun Nanofibers. Foods, 12(7), 1363. https://doi.org/10.3390/foods12071363  (IF:5.2) (Corresponding Author)
  5. Ruchika, Kumari, S., Dhiman, P., Singh, D., Saneja, A.* (2022). R-α-Lipoic Acid Conjugated to d-α-Tocopherol Polyethylene Glycol 1000 Succinate: Synthesis, Characterization, and Effect on Antiseizure Activity. Journal of Agricultural and Food Chemistry, 70(25), 7674-7682. https://doi.org/10.1021/acs.jafc.2c01685  (IF:6.1) (Corresponding Author)

 

Selected Review Publications as Corresponding Author (Recent Five)

  1. Ruchika, Khan, N., Dogra S. S., Saneja, A.* (2024). The Dawning Era of Oral Thin Films for Nutraceutical Delivery: From Laboratory to Clinic. Biotechnology Advances  108362 https://doi.org/10.1016/j.biotechadv.2024.108362 (IF:16)
  2. Khan, N., Slathia G., Kaliya, K., Saneja, A.* (2023). Recent progress in covalent organic frameworks for cancer therapy. Drug Discovery Today, 28, 6, 103602. https://doi.org/10.1016/j.drudis.2023.103602  (IF:7.4)
  3. Ruchika, Sharma, A., Saneja, A.* (2022). Zebrafish as a powerful alternative model organism for preclinical investigation of nanomedicines. Drug Discovery Today, Volume 27, Issue 5, Pages 1513-1522. https://doi.org/10.1016/j.drudis.2022.02.011 (IF:7.4)
  4. Khan, N., Ruchika, Dhritlahre, R. K., Saneja, A.* (2022). Recent advances in dual-ligand targeted nanocarriers for cancer therapy. Drug Discovery Today, 27, 8, 2288-2299. https://doi.org/10.1016/j.drudis.2022.04.011  (IF:7.4)
  5. Dhritlahre, R. K., Ruchika, Padwad, Y., Saneja, A.* (2021). Self-emulsifying formulations to augment therapeutic efficacy of nutraceuticals: From concepts to clinic. Trends in Food Science & Technology, 115, 347-365. https://doi.org/10.1016/j.tifs.2021.06.046 (IF:15.3)

 

 

Book Chapters as Corresponding Author

 

  1. Ruchika, Dhritlahre, R. K., & Saneja, A.* (2022). Nano-delivery of Bioactive Constituents from Apple Pomace. In Sustainable Agriculture Reviews 56: Bioconversion of Food and Agricultural Waste into Value-added Materials (pp. 67-85). Cham: Springer International Publishing. (Corresponding Author)
  2. Ruchika, Saneja, A.* (2022). Valorization of Sitosterol from Agricultural Waste as Therapeutic Agent. In Sustainable Agriculture Reviews 56: Bioconversion of Food and Agricultural Waste into Value-added Materials (pp. 115-142). Cham: Springer International Publishing. (Corresponding Author)

 

Books Edited

 

  • Saneja A, Panda AK, Lichtfouse E, Pharmaceutical Technology for Natural Products Delivery 1. Fundamentals and Applications, in series Sustainable Agriculture Reviews (SPRINGER NATURE, Switzerland) in press [ISBN: 978-3-030-41837-3]
  • Saneja A, Panda AK, Lichtfouse E, Pharmaceutical Technology for Natural Products Delivery 2. Impact of Nanotechnology, in series Sustainable Agriculture Reviews (SPRINGER NATURE, Switzerland) in press [ISBN: 978-3-030-41841-0]
  • Rana A, Saneja A, Kumar S, Lichtfouse E, Bioconversion of Food and Agricultural Waste into Value-added Materials, in series Sustainable Agriculture Reviews (SPRINGER NATURE, Switzerland) in press [ISBN: 978-3-030-84405-9]

Invited Talks (Recent Five)

 

  • Delivered Invited talk entitled “Polymeric Conjugation Based Approaches for Augmenting the Therapeutic Efficacy of Natural Products” in Symposium on Advances in the Natural Products Research, at National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad on 19 November, 2022

 

  • Delivered Invited talk entitled “Science Meets Sustainability: Bioconversion of Food and Agricultural Waste into  Value-Added Materials” in National Conference in Transformation in Sustainable Development in Indiaat SCVB Government College Palampur on 11th April, 2023.

 

  • Delivered Invited talk entitled “Deciphering the Complexation Mechanism of Nutraceuticals with Cyclodextrin Derivatives and its Translational Potential for Development of Oral Thin Films” in 6th Internation Conference on Nutraceutical and Chronic Diseases held at Punjab University, Chandigarh on 22nd February, 2024.

 

  • Delivered Invited talk entitled “Microbial Polysaccharide-Based Oral Thin Films for Nutraceutical Delivery: A Case Study of Pullulan” in 4th International Symposim on Ciliate Biology on Exploring the Microbial World from Human Health to Environmental Sustainability held at Delhi  University, Delhi on 4th April, 2024.

 

  • Delivered Keynote talk entitled “Orally Fast Dissolving Electrospun Nanofibers for Nutraceutical Delivery” in International Conference on Pharmaceutical Innovations & Spirit : The Annual Techno-Pharma Conclave held at Indian Institute of Technology (BHU), Varanasi on 7th April, 2024.

 

Workshop/Trainings Organized

 

  • Organized Hands on Training Program on “Development of Nutraceutical Based Formulations and Their Characterization” from 22nd to 28th November, 2022 funded by SERB

 

  • Organized High End Workshop on “Nanotechnology in Nutraceutical Delivery” from 18th to 24th July, 2023 funded by SERB

 

  • Organized Training Program on “Development of Entrepreneurship and Skill Development on Nutraceutical Delivery Systems” under Entrepreneurship Skill Development Programmes (ESDP) Scheme from 15th January 2024 to 19th January 2024 funded by MSME.
 PhD Fellow:
 
Mr. Rakesh Kumar Dhritlahre, JRF (UGC)
Ms. Ruchika, JRF (CSIR)
Mr. Nabab Khan (CSIR GPAT JRF)
Ms. Kajal Kalia, SRF 
 
Motivated aspirants having their own fellowship like CSIR/UGC/DBT/INSPIRE are welcome to contact.

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